25 articles - From Friday Sep 02 2022 to Friday Sep 09 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Kidney Dis |
| Nephrol Dial Transplant |
Kidney transplantation during mass disasters - from COVID-19 to other catastrophes A Consensus Statement by the DESCARTES Working Group and Ethics Committee of the ERA. If it comes down to save as many lives as possible, some ethical principles may vary in function of disaster circumstances, but elementary ethical rules are non-negotiable. Patient education is essential to minimize disaster-related complications and to allow for an efficient use of health care resources. |
meta-analyses and systematic reviews
| Nephrol Dial Transplant |
Effect of angiotensin converting enzyme inhibitors or angiotensin receptor blockers on cardiovascular outcomes in dialysis patients: a systematic review and meta-analysis. The present meta-analysis showed that among patients on dialysis, the use of ACEIs/ARBs is not associated with a significantly lower risk of cardiovascular events and all-cause mortality as compared with placebo or no add-on treatment. |
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
Efficacy and Safety of Belimumab in Patients With Lupus Nephritis: Subgroup Analyses of a Phase 3 Randomized Trial in the East Asian Population. Safety and efficacy profiles were consistent with BLISS-LN overall population, supporting benefits of belimumab treatment in the East Asian population with LN. |
Supermarket Proximity and Risk of Hypertension, Diabetes, and CKD: A Retrospective Cohort Study. There are significant disparities in supermarket proximity and incidence of hypertension, diabetes and CKD in Chicago, IL. The relationship between supermarket access and chronic disease is largely explained by individual and neighborhood-level factors. |
| Kidney Int |
A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron. This study reconstructs the cellular makeup of the pronephric kidney and identifies conserved cells, segments, and associated gene expression profiles. Thus, our data highlight significant conservation in podocytes, proximal, and distal tubule cells, and divergence in cellular composition underlying the capacity of each nephron to remove wastes in the form of urine, while emphasizing the Xenopus pronephros as a model for physiology and disease. |
Factor H Related Proteins Modulate Complement Activation on Kidney Cells. However, only FHR E caused glomerular complement dysregulation when injected in vivo but did not exacerbate injury when injected into mice with ischemic acute kidney injury, an alternative pathway-mediated model. Thus, our experiments demonstrate that the FHRs have unique, and likely context-dependent, effects on the different cell types within the kidney. |
Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis. Additionally, FROUNT was expressed in CD68 + monocytes/macrophages infiltrating the crescentic glomeruli in human anti-GBM glomerulonephritis. Thus, disulfiram can be a highly effective and safe drug for the treatment of glomerulonephritis by blocking the chemotactic responses of monocytes/macrophages and their activation status in the glomerulus. |
Long-Term Immunological Outcomes of Early Subclinical Inflammation on Surveillance Kidney Allograft Biopsies. Overall, SCI detected through surveillance biopsy within the first year post-transplant is a harbinger for subsequent immunological events and is associated with a significantly greater hazard for subsequent C-BPAR and death censored graft loss. Thus, our study highlights the need for identifying patients with SCI through surveillance biopsy and develop strategies to prevent further alloimmune injuries. |
Molecular Programs Associated with Glomerular Hyperfiltration in Early Diabetic Kidney Disease. A glomerular 1240-gene transcriptional signature identified in the hyperfiltration group was enriched for endothelial stress response signaling genes, including endothelin-1, tec-kinase and transforming growth factor-ß1 pathways, with the majority of the transcripts mapped to endothelial and inflammatory cell clusters in kidney single cell transcriptional data. Thus, our analysis reveals molecular pathomechanisms associated with hyperfiltration in early diabetic kidney disease involving putative ligand-receptor pairs with downstream intracellular targets linked to cellular crosstalk between endothelial and mesangial cells. |
Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Inhibition of GPX4 by RSL3 promoted VSMC calcification. Thus, repression of the SLC7A11/GSH/GPX4 axis triggers ferroptosis of VSMCs to promote vascular calcification under CKD conditions, providing a novel targeting strategy for vascular calcification. |
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury. We also describe an AKI-specific abundant urinary excretion of adaptive progenitor-like cells. Thus, single cell transcriptomics of kidney cells excreted in urine provides noninvasive, unprecedented insight into cellular processes underlying AKI, thereby opening novel opportunities for target identification, AKI sub-categorization, and monitoring of natural disease course and interventions. |
| Nephrol Dial Transplant |
Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study. The overall results, including data on specificity, suggest that calcium scores of the coronary and carotid arteries have the most potential for identifying patients with CKD at high cardiovascular risk and for evaluating new therapies. |
Efficacy and safety of methylprednisolone pulse followed by oral prednisone versus oral prednisone alone in sarcoidosis tubulointerstitial nephritis. A randomized, open-label, controlled clinical trial. As compared with a standard oral-steroid regimen, intravenous MP may have no supplemental benefit for renal function in patients with TIN due to sarcoidosis. ClinicalTrials.gov NCT01652417; EudraCT 2012-000149-11. |
Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant. An EV-based signature, reflecting the cardiovascular profile of the recipient, and the repairing/regenerative features of the graft, could be introduced as a non-invasive tool for a tailored management of follow-up of patients undergoing kidney transplant. |
Kidney transplantation during mass disasters - from COVID-19 to other catastrophes. If it comes down to save as many lives as possible, some ethical principles may vary in function of disaster circumstances, but elementary ethical rules are non-negotiable. Patient education is essential to minimize disaster-related complications and to allow for an efficient use of health care resources. |
Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects. Sequential therapy with RTX effectively reduces relapses in patients with difficult-to-treat steroid- and/or CNI-dependent or CNI-refractory nephrotic syndrome. Therapy is associated with high rates of hypogammaglobulinemia and infusion reactions. |
Utilisation and clinical outcomes of kidney transplants from deceased donors with albuminuria in the UK: a national cohort study. Our study suggests reluctance in the UK to utilise kidneys from deceased donors with dipstick albuminuria but no evidence of an association with graft survival or function. This may represent a potential to expand organ utilisation without negatively impacting transplant outcomes. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Kidney Dis |
Aldosterone, Mineralocorticoid Receptor Activation, and CKD: A Review of Evolving Treatment Paradigms. Although the FIDELIO-DKD and FIGARO-DKD clinical trials focused solely on patients with type 2 diabetes mellitus, we propose that MR activation and the resulting inflammation and fibrosis act as a substantive pathogenetic mediator not only in people with diabetic CKD but also in those with CKD without diabetes. We close by briefly discussing both recently initiated and future clinical trials that focus on extending the attributes of MR antagonism to a wider array of nondiabetic kidney disorders, such as patients with nonalbuminuric CKD. |
| Nat Rev Nephrol |
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease. Other approaches to target innate immune pathways are now under investigation for their ability to reduce cardiovascular events and slow disease progression among patients with atherosclerosis and stage 3 and 4 CKD. This Review summarizes current understanding of the role of inflammation in the pathogenesis of CKD and its associated CVD, and how this knowledge may translate into novel therapeutics. |
| Nephrol Dial Transplant |
misc publications eg case reports, tools of the trade, images of the month, etc…